Myocardial angiogenesis: its absence makes the growing heart founder.
Level V
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Abstract
Angiogenesis is essential for normal and neoplastic tissue growth. In a recent issue of Nature, Komuro and colleagues (Sano et al., 2007) describe how p53 expression in hypertrophying heart muscle impairs HIF-1-mediated neovascularization and contributes to functional decompensation of pressure-overload cardiac hypertrophy.
Medical subject headings
- Cardiomegaly
- Heart
- Hypoxia-Inducible Factor 1
- Neovascularization, Physiologic
- Signal Transduction
- Tumor Suppressor Protein p53