Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 17496198.
- Also identified by PMC identifier 2597950.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The gene for insulin-degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late-onset Alzheimer's disease (AD) based on its ability to degrade amyloid beta-protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
Medical subject headings
- Alzheimer Disease
- Insulysin
- Polymorphism, Single Nucleotide