Immunological synapses: breaking up may be good to do.
basic_science · Level V
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Abstract
Activated T cells form stable immunological synapses with antigen-presenting cells whereas naïve T cells initially engage in more transient interactions. Sims et al. (2007) demonstrate that these transient interactions are due to the kinase PKCtheta, which serves to destabilize the synapse thereby permitting T cells to migrate elsewhere. They also show that re-establishment of a synapse involves the actin regulator WASp.
Medical subject headings
- Cell Communication
- Lymphocyte Activation
- T-Lymphocytes