Engineering synthetic signaling proteins with ultrasensitive input/output control.
basic_science · Level V
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- Record sourced from PubMed, PMID 17515908.
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Abstract
Many signaling proteins are built from simple, modular components, yet display highly complex signal-processing behavior. Here we explore how modular domains can be used to build an ultrasensitive switch--a nonlinear input/output function that is central to many complex biological behaviors. By systematically altering the number and affinity of modular autoinhibitory interactions, we show that we can predictably convert a simple linear signaling protein into an ultrasensitive switch.
Medical subject headings
- Algorithms
- Intracellular Signaling Peptides and Proteins
- Models, Biological
- Protein Engineering
- Signal Transduction