Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient.
case_report · Level V
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Abstract
We report a stem cell transplant recipient who developed human herpesvirus 6 encephalitis. Human herpesvirus 6 load indicated massive intrathecal viral replication. Administration of cidofovir followed by foscarnet was associated with total clearance of human herpesvirus 6 infection. Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis.
Medical subject headings
- Antiviral Agents
- Cytosine
- Encephalitis, Viral
- Foscarnet
- Herpesvirus 6, Human
- Organophosphonates
- Roseolovirus Infections