Use of peripheral blood DNA for genotype antiretroviral resistance testing in drug-naive HIV-infected subjects.
cross_sectional · Level IV
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Abstract
Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted antiretroviral resistance.
Medical subject headings
- Anti-Retroviral Agents
- DNA, Viral
- Drug Resistance, Viral
- HIV
- HIV Infections
- Leukocytes, Mononuclear