Model based sensitivity analysis of EMG-force relation with respect to motor unit properties: applications to muscle paresis in stroke.

Abstract

The sensitivity of the electromyogram (EMG)-force relation to changes in motoneuron and muscle properties was explored using a simulation approach, and by applying existing motoneuron pool, muscle force, and surface EMG models. The simulation results indicate that several factors contribute potently to known changes in the EMG-force relation in paretic stroke muscles. First, compression of the motor unit recruitment range with respect to the injected current tends to generate greater EMG amplitude at a given force, and to produce a highly nonlinear EMG-force relation. The overall mean slope of the EMG-force relation tends to be flatter, primarily because of this non-linear behavior. Second, with reductions of the mean motor unit firing rates, the slope of the EMG-force relation also tends to increase especially as the mean firing rates dropped substantially below the motor unit fusion frequency. Finally, similar effects were observed with a reduction in the number of motor units, and with variation in motor unit contractile properties, which also altered the EMG-force relation. These findings provide new insight toward our understanding of experimental EMG-force relations in both normal and pathological states, such as the abnormal EMG-force relations of paresis muscles in stroke.