Stopping ras in its tracks.
basic_science · Level V
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Abstract
Ras interacts with many downstream effectors that regulate complex cytoplasmic signaling networks. In this issue, Gupta et al. (2007) use mouse models of Ras-mediated tumorigenesis to show that the interaction of Ras with a single isoform of phosphatidylinositol 3-kinase (PI3K), called p110alpha (PIK3CA), is critical for tumor formation. This result will stimulate re-evaluation of pharmacological approaches to target Ras for cancer treatment.
Medical subject headings
- Metabolic Networks and Pathways
- Phosphatidylinositol 3-Kinases
- ras Proteins