After hours keeps clock researchers CRYing Overtime.
basic_science · Level V
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- Record sourced from PubMed, PMID 17540165.
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Abstract
Three recent reports, including one in this issue of Cell, reveal that the circadian regulator CRY is targeted for degradation by the F box E3 ubiquitin ligase FBXL3 (Siepka et al., 2007; Busino et al., 2007; Godinho et al., 2007). These studies confirm the importance of targeted protein degradation as a key design feature of the mammalian circadian clock.
Medical subject headings
- Biological Clocks
- Circadian Rhythm
- F-Box Proteins
- Flavoproteins