Filling a GAP(DH) in caspase-independent cell death.
editorial · Level V
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- Record sourced from PubMed, PMID 17540167.
- Also identified by PMC identifier 2592604.
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Abstract
Mitochondrial outer-membrane permeabilization can lead to cell death even without activation of caspases. In this issue of Cell, Colell et al. (2007) identify the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase as a potent inhibitor of caspase-independent cell death that may allow metabolically active cells to survive mitochondrial insult.
Medical subject headings
- Apoptosis
- Cell Survival
- Glyceraldehyde-3-Phosphate Dehydrogenases