TXNIP links redox circuitry to glucose control.
editorial · Level V
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Abstract
Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A new study (Parikh et al., 2007) implicates this redox rheostat as a negative regulator of peripheral glucose metabolism in humans. Investigators combined human physiology, genomic screening, and cell-based genetic studies to highlight TNXIP as a potential culprit in the pathogenesis of type 2 diabetes.
Medical subject headings
- Carrier Proteins
- Diabetes Mellitus, Type 2
- Glucose
- Thioredoxins