Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 17551080.
- Also identified by PMC identifier 2740896.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogenic mutations of mitochondrial DNA (mtDNA) can cause diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising the possibility that genetic variants of mtDNA alter the risk of developing the disorder. Recent studies have produced conflicting results. By studying 897 UK cases of type 2 diabetes and 1010 population-matched controls, it is shown that European mtDNA haplogroups are unlikely to play a major role in the risk of developing the disorder.
Medical subject headings
- DNA, Mitochondrial
- Diabetes Mellitus, Type 2
- Haplotypes