Diabetic nephropathy and proximal tubule ROS: challenging our glomerulocentricity.
Level V
Where this comes from
- Record sourced from PubMed, PMID 17554351.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.
Medical subject headings
- Diabetic Nephropathies
- Kidney Glomerulus
- Kidney Tubules, Proximal
- Reactive Oxygen Species