Cutaneous responses to vaccinia in individuals with previous smallpox vaccination.
case_control · Level III
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- Record sourced from PubMed, PMID 17560685.
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Abstract
The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.
Medical subject headings
- Skin
- Vaccinia