Two kinase family dramas.
basic_science · Level V
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- Record sourced from PubMed, PMID 17574014.
- Also identified by PMC identifier 2040498.
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Abstract
In this issue, Lietha and colleagues (2007) report the structure of focal adhesion kinase (FAK) and reveal how FAK maintains an autoinhibited state. Together with the structure of another tyrosine kinase, ZAP-70 (Deindl et al., 2007), this work highlights the diversity of mechanisms that nature has evolved within the kinase superfamily to regulate their activity through autoinhibition.
Medical subject headings
- Focal Adhesion Protein-Tyrosine Kinases
- ZAP-70 Protein-Tyrosine Kinase