All roads lead to IKKepsilon.
basic_science · Level V
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- Record sourced from PubMed, PMID 17574017.
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Abstract
Extensive genetic alterations have been found in many epithelial malignancies. Using three complementary genetic approaches, Boehm et al. (2007) identify IKBKE--which encodes IKKepsilon, a component of the NF-kappaB pathway--as a breast cancer oncogene.
Medical subject headings
- Breast Neoplasms
- Gene Expression Regulation, Neoplastic
- I-kappa B Kinase
- NF-kappa B