Disrupting the stem cell niche: good seeds in bad soil.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17574018.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Stem cells reside in a microenvironment or niche that is critical for stem cell maintenance and regulation. But what happens when a stem cell niche is disrupted? In this issue of Cell, two reports (Walkley et al., 2007a, 2007b) demonstrate in mice that alterations in the niche for hematopoietic stem cells lead to the development of myeloproliferative disease.
Medical subject headings
- Hematopoietic Stem Cells
- Myeloproliferative Disorders