The HBV drug entecavir - effects on HIV-1 replication and resistance.
case_series · Level IV
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- Record sourced from PubMed, PMID 17582071.
- Also identified by PMC identifier 3069686.
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Abstract
Entecavir, a drug approved by the Food and Drug Administration for the treatment of chronic hepatitis B virus (HBV) infection, is not believed to inhibit replication of human immunodeficiency virus type 1 (HIV-1) at clinically relevant doses. We observed that entecavir led to a consistent 1-log(10) decrease in HIV-1 RNA in three persons with HIV-1 and HBV coinfection, and we obtained supportive in vitro evidence that entecavir is a potent partial inhibitor of HIV-1 replication. Detailed analysis showed that in one of these patients, entecavir monotherapy led to an accumulation of HIV-1 variants with the lamivudine-resistant mutation, M184V. In vitro experiments showed that M184V confers resistance to entecavir. Until more is known about HIV-1-resistance patterns and their selection by entecavir, caution is needed with the use of entecavir in persons with HIV-1 and HBV coinfection who are not receiving fully suppressive antiretroviral regimens.
Medical subject headings
- Antiviral Agents
- Guanine
- HIV Infections
- HIV-1
- Hepatitis B
- Reverse Transcriptase Inhibitors
- Virus Replication