HaploBuild: an algorithm to construct non-contiguous associated haplotypes in family based genetic studies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17586827.
- Also identified by PMC identifier 2665175.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have created a program that searches densely genotyped regions for associated non-contiguous haplotypes using a standard family based haplotype association test. This program was designed to expand upon the 'sliding window' methodologies commonly used for haplotype construction by allowing the association of subsets of single nucleotide polymorphisms (SNPs) to drive the construction of the haplotype. This strategy permits HaploBuild to construct more biologically relevant haplotypes that are not constrained by arbitrary length and contiguous orientation. http://snp.bumc.bu.edu.
Medical subject headings
- Algorithms
- Contig Mapping
- Genetic Linkage
- Genetic Variation
- Genetics, Population
- Haplotypes
- Pedigree