Tumor necrosis factor-alpha in cisplatin nephrotoxicity: a homebred foe?
other · Level V
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Abstract
A robust inflammatory response involving tumor necrosis factor-alpha (TNF-alpha) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-alpha. Blockade of TNF-alpha attenuates inflammation and associated kidney injury.
Medical subject headings
- Antineoplastic Agents
- Cisplatin
- Renal Insufficiency
- Tumor Necrosis Factor-alpha