Need for speed: mechanical regulation of a replicative helicase.
basic_science · Level V
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Abstract
There is much debate about how helicases unwind DNA during DNA replication and how their activity is regulated. In this issue, Johnson et al. (2007) shed light on this conundrum using a single molecule approach to dissect the behavior of the T7 DNA helicase.
Medical subject headings
- DNA
- DNA Helicases
- DNA Replication
- DNA, Single-Stranded