The X factor: skewing X inactivation towards cancer.
review · Level V
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Abstract
Increased expression of the epidermal growth factor receptor HER-2/ErbB2 is frequently observed in breast cancer and is targeted by the anticancer drug Herceptin. Now, Zuo et al. (2007) reveal that an X-linked gene encoding the transcription factor FOXP3 is a breast cancer tumor suppressor that represses expression of HER2/ErbB2.
Medical subject headings
- Cell Transformation, Neoplastic
- Chromosomes, Human, X
- Forkhead Transcription Factors
- Erb-b2 Receptor Tyrosine Kinases
- Tumor Suppressor Proteins
- X Chromosome Inactivation