The primary cilium: keeper of the key to cell division.
review · Level V
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Abstract
Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.
Medical subject headings
- Centrosome
- Cilia
- Mitosis
- Phosphotransferases
- Spindle Apparatus