Src phosphorylation of cortactin enhances actin assembly.
basic_science · Level V
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- Record sourced from PubMed, PMID 17606906.
- Also identified by PMC identifier 1924558.
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Abstract
Src kinase mediates growth factor signaling and causes oncogenic transformation, which includes dramatic changes in the actin cytoskeleton, cell shape, and motility. Cortactin was discovered as a substrate for Src. How phosphorylation of cortactin can enhance actin assembly is unknown. Here, using an actin assembly system reconstituted from purified components, we demonstrate for the first time a biochemical mechanism by which Src phosphorylation of cortactin affects actin assembly. The adaptor Nck is an important component of the system, linking phosphorylated cortactin with neuronal WASp (N-WASp) and WASp-interacting protein (WIP) to activate Arp2/3 complex.
Medical subject headings
- Actins
- Cortactin
- Proto-Oncogene Proteins pp60(c-src)