Computational design of an RNA hexagonal nanoring and an RNA nanotube.
basic_science · Level V
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Abstract
The combination of computer modeling, RNA structure versatility, and siRNA function can be efficiently used to design an all-RNA nanoparticle capable of siRNA delivery. Here, we present a computational design of an RNA nanoring and a nanotube. An RNA nanoring consists of six simple linear building blocks that are assembled together via known noncovalent loop-loop contacts based on RNAI/RNAII inverse sequences. The helical sequences of the building blocks can include siRNAs for drug delivery.
Medical subject headings
- Drug Carriers
- Models, Chemical
- Nanostructures
- Nanotechnology
- RNA