The role of vascular cell adhesion molecule-1 in tumor immune evasion.
review · Level V
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- Record sourced from PubMed, PMID 17616653.
- Also identified by PMC identifier 3179385.
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Abstract
Tumor immune escape is a critical trait of cancer but the mechanisms involved have yet to fully emerge. One recent study has shown that tumor cells can escape T-cell immunity by overexpressing the endothelial cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), which normally mediates leukocyte extravasion to sites of tissue inflammation. Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape.
Medical subject headings
- Carcinoma, Renal Cell
- Liver Neoplasms
- Neoplasms
- Vascular Cell Adhesion Molecule-1