TOR signaling and S6 kinase 1: Yeast catches up.
review · Level V
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Abstract
Conservation of the rapamycin-sensitive TOR signaling network among eukaryotes has been instrumental to the rapid progress made in this field in recent years. A recent report in Molecular Cell (Urban et al., 2007) now extends this conservation to include Sch9, an AGC protein kinase family member from S. cerevisiae, which appears to be the long sought after yeast ortholog of mammalian S6 kinase 1 (S6K1) and a direct target for the rapamycin-sensitive TOR complex I.
Medical subject headings
- Protein Kinases
- Ribosomal Protein S6 Kinases
- Saccharomyces cerevisiae
- Signal Transduction