Inhibition of tubule-cell proliferation to prevent cyst formation: a new avenue to treat ADPKD?
editorial · Level V
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Abstract
Tubule-cell hyperproliferation precedes cyst development in autosomal dominant polycystic kidney disease (ADPKD). Parker et al. report that insulin-like growth factor-1 stimulates ADPKD cell proliferation by activating Ras and Raf; inhibition of Ras or Raf abolished this effect. Inhibiting tubule-cell proliferation could halt cyst formation and prolong survival of functional tubules, offering a new treatment for ADPKD patients.
Medical subject headings
- Cell Proliferation
- Kidney Tubules
- Polycystic Kidney, Autosomal Dominant