Remodeling chromatin for senescence.
editorial · Level V
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Abstract
Cellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co-workers describe new insights into the protein complexes that regulate these changes in chromatin structure.
Medical subject headings
- Cellular Senescence
- Chromatin Assembly and Disassembly
- Chromosomes, Human
- Heterochromatin