A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum.
basic_science · Level V
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Abstract
Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in (glyco)protein quality control.