Vitamin D receptor: a highly versatile nuclear receptor.
Level V
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Abstract
Vitamin D receptor (VDR) modulators are used to treat hyperparathyroidism secondary to chronic kidney disease (CKD). The therapy is associated with reduced mortality in stage 5 CKD patients, who experience an extremely high cardiovascular disease (CVD)-related mortality rate. Chen et al. report that VDR is involved in regulating type A natriuretic peptide receptor (NPR-A) in inner medullary collecting duct cells. The regulation of NPR-A may be one of several mechanisms by which VDR activation reduces CVD risk in CKD.
Medical subject headings
- Guanylate Cyclase
- Receptors, Atrial Natriuretic Factor
- Receptors, Calcitriol
- Receptors, Cytoplasmic and Nuclear