IgA nephropathy: immune mechanisms beyond IgA mesangial deposition.
editorial · Level V
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- Record sourced from PubMed, PMID 17653232.
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Abstract
IgA nephropathy is attributable to mesangial IgA immune complex deposition. The pathogenic potential of frequently colocalized IgG deposits may depend on polarized T-helper cytokines that modulate Fcgamma receptors of infiltrating macrophages, leading to either activation or inhibition that determines glomerular injury.
Medical subject headings
- Glomerulonephritis, IGA
- Immunoglobulin A
- Mesangial Cells