Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.
case_report · Level V
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Abstract
The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis. In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive. We assume that rIFN-gamma induced the de novo development of SLE in our patient.
Medical subject headings
- Arthritis, Rheumatoid
- Interferon-gamma
- Lupus Erythematosus, Systemic
- Ribonucleoproteins, Small Nuclear