Mitochondrial DNA transcription: regulating the power supply.
editorial · Level V
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Abstract
In this issue of Cell, Park et al. (2007) describe the nuclear encoded protein MTERF3 as a negative regulator of mitochondrial DNA transcription initiation. This study highlights a mechanism by which mitochondrial DNA transcription (and therefore oxidative phosphorylation) may be regulated in response to alterations in the cell's physiological and metabolic demands.
Medical subject headings
- DNA, Mitochondrial
- Transcription, Genetic