Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications.
review · Level V
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- Record sourced from PubMed, PMID 17671640.
- Also identified by PMC identifier 1934569.
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Abstract
There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
Medical subject headings
- Chromosome Aberrations
- Gene Expression Regulation, Neoplastic
- MicroRNAs
- Neoplasms
- Quantitative Trait Loci