"AMPing up" our understanding of the hypothalamic control of energy balance.
other · Level V
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- Record sourced from PubMed, PMID 17671647.
- Also identified by PMC identifier 1934582.
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Abstract
AMP-activated protein kinase (AMPK) has emerged as a metabolic "fuel gauge," which oscillates between anabolic and catabolic processes that ultimately influence energy balance. A study in this issue of the JCI by Claret et al. now extends the role of AMPK in medial basal hypothalamic neurons (see the related article beginning on page 2325). These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis.
Medical subject headings
- Energy Metabolism
- Homeostasis
- Hypothalamus
- Intercellular Signaling Peptides and Proteins
- Multienzyme Complexes
- Neurons
- Pro-Opiomelanocortin
- Protein Serine-Threonine Kinases