PERIOD-TIMELESS interval timer may require an additional feedback loop.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17676950.
- Also identified by PMC identifier 1937016.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic "interval timer" created by PERIOD-TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedback into a full circadian model produced results that are consistent with previous experimental observations of wild-type protein profiles and numerous mutant phenotypes.
Medical subject headings
- Biological Clocks
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Feedback
- Models, Biological
- Nuclear Proteins