Quantitative analysis of cell nucleus organisation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 17676980.
- Also identified by PMC identifier 1933473.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work.
Medical subject headings
- Cell Nucleus
- Models, Biological
- Nuclear Proteins