In vivo two-photon fluorescence microscopy opens a new area for investigation of the excretion of cationic drugs in the kidney.
basic_science · Level V
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Abstract
Polyspecific transporters mediate excretion and reabsorption of organic cations in kidney. With in vivo two-photon fluorescence microscopy, excretion and reabsorption of a fluorescent cation in rat renal proximal tubules was resolved. In combination with specific inhibitors, the contribution of individual cation transporters can be determined.
Medical subject headings
- Drug Evaluation, Preclinical
- Kidney
- Microscopy, Confocal
- Microscopy, Fluorescence, Multiphoton
- Microscopy, Video
- Organic Cation Transport Proteins