Fetal to adult stem cell transition: knocking Sox17 off.
basic_science · Level V
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- Record sourced from PubMed, PMID 17693249.
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Abstract
What controls the inherent differences between fetal and adult hematopoietic stem cells (HSCs)? In this issue of Cell, Kim et al. (2007) demonstrate in mice that the endodermal transcription factor Sox17 is required for the maintenance of fetal and neonatal but not adult HSCs.
Medical subject headings
- Adult Stem Cells
- Fetal Stem Cells
- HMGB Proteins
- Transcription Factors