Clearance of amyloid-beta by circulating lipoprotein receptors.
basic_science · Level V
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- Record sourced from PubMed, PMID 17694066.
- Also identified by PMC identifier 2936449.
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Abstract
Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (Abeta) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Abeta in humans. Recombinant LRP cluster IV (LRP-IV) bound Abeta in plasma in mice and Alzheimer's disease-affected humans with compromised sLRP-mediated Abeta binding, and reduced Abeta-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Abeta.
Medical subject headings
- Amyloid beta-Peptides
- Brain
- Capillaries
- Cerebrovascular Circulation
- Low Density Lipoprotein Receptor-Related Protein-1