Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection.
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Abstract
The discovery of somatic mutations in cancer tissue is extremely laborious, time-consuming and costly. In an evaluation comparing mismatch repair detection (MRD) against Sanger sequencing for somatic-mutation detection, we found that MRD had a specificity of 96% and a sensitivity of 92%. Our results showed that MRD is a robust and cost-effective alternative to Sanger sequencing for identifying somatic mutations in human tumors.
Medical subject headings
- Base Pair Mismatch
- DNA, Neoplasm
- Escherichia coli
- Mutation
- Neoplasms