Muscle strength recovery in treated Guillain-Barré syndrome: a prospective study for the first 18 months after onset.

Abstract

To assess the recovery in muscle strength and functional capacities in subjects with Guillain-Barré syndrome (GBS) for 18 months after onset. Six GBS patients were treated and transferred to our rehabilitation center within the first week of recovery. Isometric and isokinetic strength increased significantly during the first 6 months (P < 0.01). Between 6 and 18 months, muscle strength increased less rapidly (P < 0.05). We showed a significant negative correlation between plateau period duration and knee extensors, elbow flexors muscles strength recovery (rho = -0.82; P = 0.05). At 6 months, manual muscle testing and functional independence motor total scores were close to normal levels. At 18 months, all patients satisfied the criteria for a full recovery. However, they felt difficulties after prolonged exercise. Until 18 months of recovery, dynamometric measures still showed significant strength improvement. This underscores the need for a minimal 24 months of clinical follow-up with an individualized rehabilitation management program.