Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
basic_science · Level V
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- Record sourced from PubMed, PMID 17721546.
- Also identified by PMC identifier 2584972.
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Abstract
We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.
Medical subject headings
- Acquired Immunodeficiency Syndrome
- CD4 Antigens
- HIV-1