Aging: all in the head?
basic_science · Level V
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- Record sourced from PubMed, PMID 17767900.
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Abstract
Global reduction in insulin signaling has been linked to extended life span in a range of organisms. New work on mice with brain-specific or whole-body reductions in insulin receptor substrate 2 (IRS2) (Taguchi et al., 2007) points to a role for insulin/IGF-1 signaling in the central control of mammalian aging.
Medical subject headings
- Aging
- Insulin
- Signal Transduction