The osteoclast-not always guilty.
basic_science · Level V
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- Record sourced from PubMed, PMID 17767902.
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Abstract
Osteopetrosis is usually regarded as the disease of nonfunctioning osteoclasts, with a consequent accumulation of osseocartilaginous material in the bone marrow. A recent report shows that, in some patients with the rare autosomal recessive form of the disease, the osteoclast defect may be non-cell autonomous, in this case due to a mutation in RANKL, the protein that normally controls osteoclast formation and activity.
Medical subject headings
- Osteoclasts
- Osteopetrosis