A fight for neurotransmission: SCRAPPER trashes RIM.
basic_science · Level V
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- Record sourced from PubMed, PMID 17803899.
- Also identified by PMC identifier 2821330.
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Abstract
The presynaptic scaffold molecule RIM1alpha is important for regulating neurotransmitter release. In this issue, Yao et al. (2007) show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1alpha for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check.
Medical subject headings
- Brain
- GTP-Binding Proteins
- Protein Processing, Post-Translational
- Synapses
- Synaptic Transmission
- Synaptic Vesicles
- Ubiquitin
- Ubiquitin-Protein Ligases