Connecting the dots between septins and the DNA damage checkpoint.
editorial · Level V
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Abstract
In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK. As NCK controls actin dynamics, this pathway may connect DNA damage responses and cellular morphology in metazoans.
Medical subject headings
- Actins
- Cell Cycle
- Cell Cycle Proteins
- Cell Nucleus
- DNA Damage
- GTP-Binding Proteins
- Nuclear Proteins
- Oncogene Proteins
- Phosphoric Monoester Hydrolases
- Suppressor of Cytokine Signaling Proteins