On the road to bacterial cell death.
editorial · Level V
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- Record sourced from PubMed, PMID 17803902.
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Abstract
How do antibiotics actually work? Although the primary cellular targets of many antimicrobial agents have been identified, the downstream events leading to bacterial cell death remain unclear. In this issue, Kohanski et al. (2007) provide evidence that the production of reactive oxygen species is a shared mechanism of cell death initiated by bactericidal antibiotics.
Medical subject headings
- Anti-Bacterial Agents
- DNA Damage
- DNA, Bacterial
- Escherichia coli
- Hydroxyl Radical
- Microbial Viability
- Oxidative Stress
- Staphylococcus aureus