Identification of potential HIV-1 targets of minocycline.
basic_science · Level V
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Abstract
Minocycline, a broad spectrum antibiotic, has been discovered to have inhibitory activity against HIV-1 in vitro, but the targets inhibited are unknown. We used a docking with dynamics protocol developed by us to predict the binding affinities of minocycline against seven active sites of five HIV-1 proteins to putatively identify the potential target(s) of minocycline. The results indicate that minocycline has the highest predicted binding affinity against HIV-1 integrase.
Medical subject headings
- HIV-1
- Minocycline
- Models, Chemical
- Models, Molecular
- Protein Interaction Mapping
- Viral Proteins